Exercise Testing, Family History, and Subclinical Atherosclerosis Markers for Cardiovascular Risk Reclassification in Middle-Aged Women

Abstract Background Cardiovascular diseases are the main cause of death in women and the accuracy of currently available risk scores is questionable. Objective To reclassify the risk estimated by the Framingham Risk Score (FRS) in asymptomatic middle-aged women by incorporating family history, exercise testing variables, and subclinical atherosclerosis markers. Methods This cross-sectional study included 509 women (age range, 46-65 years) without cardiovascular symptoms. Those at low or intermediate risk by the FRS were reclassified to a higher level considering premature family history of acute myocardial infarction and/or sudden death; four variables from exercise testing; and two variables related to subclinical atherosclerosis markers. The homogeneity of these variables according to the FRS was verified by Pearson chi-square test (p<0.05). Results According to the FRS, 80.2%, 6.2%, and 13.6% of the women were classified as low (<5%), intermediate (5-10%), and high (>10%) risks, respectively. The intermediate-risk stratum showed the highest increase (from 6.2% to 33.3%) with addition of family history; followed by addition of chronotropic index <80% (to 24.2%); functional capacity <85% (22.2%), coronary calcium score >0 (20.6%); decreased one-minute heart rate recovery ≤12 bpm (15.2%); carotid intima-media thickness >1 mm and/or carotid plaque (13.8%) and ST-segment depression (9.0%). The high-risk stratum increased to 14.4% with the addition of reduced heart rate recovery and to 17.1% with the coronary calcium score. Conclusion Incorporation of premature family history of cardiovascular events, exercise testing abnormal parameters, and subclinical atherosclerosis markers into the FRS led to risk reclassification in 3.0-29.7% of asymptomatic middle-aged women, mainly by an increase from low to intermediate risk.

Aterosclerose de carótidas em mulheres na pré e pós-menopausa com antecedentes de hipertensão na gestação: estudo de caso-controle / Carotid atherosclerosis in pre-and-post-menopausal women with a history of pregnancy-induced hypertension: case-control study

A mortalidade por doença cardiovascular entre as mulheres permanece elevada. Estudos observacionais são controversos sobre a participação dos antecedentes de distúrbio hipertensivo gestacional no risco cardiovascular. Verificar a associação entre aterosclerose de carótidas em mulheres no climatério que tiveram hipertensão na gestação. Estudo de caso-controle, sendo os casos compostos por mulheres com aterosclerose de carótida, definida como espessura íntima-média carotídea > 1 mm e/ou presença de placas de carótidas; os controles não apresentavam estas alterações. Adotou-se nível de significância de 95%. Foram avaliadas 504 mulheres sem doença cardiovascular prévia, sendo 126 casos e 378 controles. Eram hipertensas 67% delas; 76% eram dislipidêmicas; e 16%, diabéticas. Cerca de 10% referiram antecedentes de hipertensão na gestação. As mulheres com aterosclerose de carótidas apresentaram valores maiores dos níveis de pressão arterial sistólica (134,18 mmHg vs. 128,59 mmHg; p = 0,008) e de LDL-colesterol (156,52 mg% vs. 139,97 mg%; p = 0,0005). Não foi encontrada diferença estatística em relação à presença de aterosclerose de carótidas e ao antecedente de hipertensão na gestação (OR 1,672; IC 95% 0,893-3,131). O antecedente de hipertensão na gestação não foi associado à aterosclerose subclínica de carótidas em mulheres na pré e pós-menopausa. No entanto, verificou-se a associação entre a aterosclerose de carótida e os fatores de risco clássicos, como pressão arterial sistólica elevada e altos níveis de LDL-colesterol

Cardiovascular disease mortality among women remains high. Observational studies are controversial about the participation of a history of gestational hypertensive disorder in cardiovascular risk. To verify the association between carotid atherosclerosis in menopausal women who had pregnancy-induced hypertension. Case-control study, with cases consisting of women with carotid atherosclerosis, defined as carotid intima-media thickness > 1 mm and/or presence of carotid plaques; the controls did not have these alterations. The significance level was set at 95%. A total of 504 women without previous cardiovascular disease were assessed, 126 cases and 378 controls. Of the total, 67% were hypertensive; 76% were dyslipidemic; and 16% were diabetic. Approximately 10% reported a history of hypertension during pregnancy. Women with carotid atherosclerosis had higher values of systolic blood pressure (134.18 mmHg vs. 128.59 mmHg, p = 0.008) and LDL-cholesterol(156.52 mg% vs. 139.97 mg%; p = 0.0005). No statistical difference was found regarding the presence of carotid atherosclerosis and history of hypertension during pregnancy (OR 1.672, 95% CI: 0.883-3.131). The history of hypertension during pregnancy was not associated with subclinical carotid atherosclerosis in menopausal women. However, an association was observed between carotid atherosclerosis and classic risk factors, such as elevated systolic blood pressure and LDL-cholesterol levels

The use of an improved intragastric balloon technique to reduce weight in pre-obese patients--preliminary results.

BACKGROUND: In this study, a new safer and faster intragastric balloon procedure was also employed to treat pre-obese patients (body mass index (BMI) < 30). METHODS: From June 2006 to June 2009, 20 such patients were submitted to the Silimed Gastric Balloon treatment, as a part of a multidisciplinary program involving clinical, psychological, and behavioral approaches. For the 16 patients who had completed the 5-6-month treatment, the initial mean weight and mean BMI were 74 kg and 27.5 kg/m(2), respectively. RESULTS: After the treatment, the mean weight and BMI values decreased significantly to 65.9 kg and 24.5 kg/m(2), respectively. There were only minor complications--nausea and vomiting--with the exception of two cases of spontaneous deflation of the devices which were successfully removed by gastric endoscopy. CONCLUSIONS: Thus, preliminary data suggest that this new intragastric balloon procedure might also be a safe and effective treatment for weight loss in pre-obese patients.

Modificações da qualidade de vida sexual de obesos submetidos à cirurgia de Fobi-Capella / Changes the sexual quality of life of the obeses submitted Fobi-Capella gastroplasty surgery

OBJETIVO: Analisar as modificações na qualidade de vida sexual de obesos, proporcionadas pela redução do peso corpóreo, após a realização da gastroplastia à Fobi-Capella. MÉTODOS: Estudo quantitativo, prospectivo e longitudinal com cortes transversais, realizado entre março de 2005 e março de 2007, com 21 obesos mórbidos. Critérios de inclusão: idade de 20 a 50 anos, índice de massa corpórea (IMC) =40 Kg/m² e insucesso em tentativas de tratamento clínico para obesidade nos últimos dois anos. Coleta de dados clínicos em prontuários e aplicação de questionário específico com questões relativas à função sexual, realizadas antes e seis meses após a cirurgia. Os escores obtidos foram analisados com o auxilio do programa Epi-Info6, empregando o teste T de student para amostras pareadas. RESULTADOS: O valor total aumentou seis meses após a cirurgia em 76,19 por cento, permaneceu inalterado em 14,29 por cento e diminuiu em 9,52 por cento. Os domínios referentes a função erétil e a relação sexual aumentaram em 71,42 por cento, ao desejo sexual em 52,38 por cento e ao orgasmo em 28,57 por cento. A satisfação sexual aumentou em 57,14 por cento. As médias do valor total e dos seus domínios antes e seis meses após a cirurgia, exceto aquelas referentes ao orgasmo e ao desejo sexual, apresentam diferenças estatisticamente significativas. CONCLUSÃO: A qualidade de vida sexual em homens obesos melhora após a realização da gastroplastia à Fobi-Capella. Evidenciaram-se modificações favoráveis na função sexual desses indivíduos após a perda de peso.

OBJECTIVES: Examine changes in the quality of sexual life of men with morbid obesity offered by a reduction in body weight following Fobi-Capella gastroplasty. METHOD: A quantitative, prospective, longitudinal, cross-sectional study was carried out on 21 men with morbid obesity between March 2005 and March 2007. Inclusion criteria were: aged 20 to 50 years, body mass index (BMI) = 40 kg/m² and failure in attempts of clinical treatment for obesity in the previous two years. Data collection from clinical records and the administering of a specific questionnaire on issues relating to sexual function was performed prior to and six months following surgery. Scores were analyzed with the help of the Epi-Info 6 program, using the Student's t-test for paired samples. RESULTS: The total score increased at the six-month post operative in 76.19 percent; remained unaltered in 14.29 percent; and decreased in 9.52 percent. Scores in areas related to erectile function and sexual relations increased in 71.42 percent; sexual desire increased in 52.38 percent; and orgasms increased in 28.57 percent. General sexual satisfaction increased in 57.14 percent. The average total score and scores on the domains of the questionnaire prior to and six months following surgery revealed statistically significant differences, except those relating to sexual desire and orgasm. CONCLUSION: The quality of sexual life in morbid obese men improves following Fobi-Capella surgery. Favorable changes occurred in sexual function after these individuals underwent this type of bariatric surgery.

[Changes the sexual quality of life of the obeses submitted Fobi-Capella gastroplasty surgery]. / Modificações da qualidade de vida sexual de obesos submetidos à cirurgia de Fobi-Capella.

OBJECTIVES: Examine changes in the quality of sexual life of men with morbid obesity offered by a reduction in body weight following Fobi-Capella gastroplasty. METHOD: A quantitative, prospective, longitudinal, cross-sectional study was carried out on 21 men with morbid obesity between March 2005 and March 2007. Inclusion criteria were: aged 20 to 50 years, body mass index (BMI) = 40 kg/m(2) and failure in attempts of clinical treatment for obesity in the previous two years. Data collection from clinical records and the administering of a specific questionnaire on issues relating to sexual function was performed prior to and six months following surgery. Scores were analyzed with the help of the Epi-Info 6 program, using the Student's t-test for paired samples. RESULTS: The total score increased at the six-month post operative in 76.19%; remained unaltered in 14.29%; and decreased in 9.52%. Scores in areas related to erectile function and sexual relations increased in 71.42%; sexual desire increased in 52.38%; and orgasms increased in 28.57%. General sexual satisfaction increased in 57.14%. The average total score and scores on the domains of the questionnaire prior to and six months following surgery revealed statistically significant differences, except those relating to sexual desire and orgasm. CONCLUSION: The quality of sexual life in morbid obese men improves following Fobi-Capella surgery. Favorable changes occurred in sexual function after these individuals underwent this type of bariatric surgery.

Onicomicose: prevenção do pé em risco nos portadores de diabetes tipo 2 / Onychomycosis: preventing the foot at risk in type 2 diabetes bearers

O objetivo do estudo foi avaliar a incidência e os fatores desencadeantes de onicomicose nos pacientes diabéticos atendidos no Programa de Diabetes de um Hospital Universitário do Recife. Tratou-se de um estudo exploratório, quantitativo, realizado com 63 pacientes portadores de diabetes atendidos no programa durante um ano. O estudo mostrou a presença de onicomicose em 40% (25) dos pacientes, sugerindo a necessidade de um programa preventivo-promocional, com enfoque no auto-cuidado, dirigido aos pacientes diabéticos.